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李犇《Interfacing supercritical fluid solubility apparatus with supercritical fluid chromatography operated with and without on-line post-column derivatization...》

英文题目:Interfacing supercritical fluid solubility apparatus with supercritical fluid chromatography operated with and without on-line post-column derivatization: Determining the solubility of caffeine and monensin in supercritical carbon dioxide

第一作者:李犇

我校署名:第一单位

所属单位:化工学院

项目来源:省、市、自治区科技项目

刊物名称:Journal of Supercritical Fluids  年:2016  卷:115  页:17-25

刊物类别:国际期刊

Web of Science 类别:Chemistry,Physical;Engineering,Chemical

研究方向:Chemistry;Engineering

Impact factor(2015):2.579

JCR分区:Q1

摘要:An interface has been developed that enables the direct coupling of a continuously stirred high pressure vessel with on-line supercritical fluid chromatography (SFC). The system provides a rapid means to determine the solubility of organic compounds in supercritical fluid carbon dioxide (SF-CO2). The method involves increasing the loaded vessel pressure in controlled steps to produce a series of progressively more saturated sample solutions for on-line SFC solubility measurements. The method was validated by obtaining mole fraction solubility data for caffeine in SF-CO2 at four different temperatures ranging from 313 K to 343 K through the pressure range 10-28 MPa. For caffeine, SFC detection was performed at 254 nm. The solubility of monensin in SF-CO2 was determined using SFC with post-column derivatization. Vanillin served as derivatizing agent with SFC detection at 520 nm. Mole fraction solubility data for monensin was obtained at 313 K and 328 K through the pressure range 10-27.5 MPa.